김동환 교수 사진
김동환 교수
영문명
Donghwan Kim
전공
동물유전공학, 기능유전체학
전화번호
055-350-5515
팩스번호
055-350-5519
이메일
donghwank@pusan.ac.kr
홈페이지
담당과목
분자생물학, 유전공학, 동물유전학
실험실
기능유전체학실험실 (Functional Genomics Lab.)

Research Interests

- Genome-Editing을 이용한 질병/경제 동물 모델 생산

- 지방 및 근육 특이적 유전자 기전 연구

- 유전자 조절을 통한 동물 생산성 증대, 질병 저항성 강화 방안 연구

- 고부가가치 동물 자원 구축

 

Academic

연 도

대 학

학 과

학 위

2006

대구대학교

생명공학과

공학학사

2009

대구대학교

생물공학과

공학석사

2019

한국과학기술연합대학원대학교

생명과학

이학박사 (기능유전체학 전공)

    

Career

연 도

소 속

직 위

2012.01 ~ 2013.08

강남차병원

연구원

2013.09 ~ 2019.02

한국생명공학연구원

연구생

2019.03 ~ 2024.08

The Ohio State University

박사 후 연구원

2024.09 ~ 현재

부산대학교

동물생명자원과학과 조교수

 

Award winning career

1. The Effects of Myostatin Mutation on the Tibia Bone Quality in Male and Female Japanese Quail. 2023. (2nd Place Poster Competition at CFAES Research Forum).

    

2. Eggshell Strength in MSTN mutant quail. 2022. (3rd Place Poster Competition at 18th Russell Klein Nutrition Research Symposium, The Ohio State University).

    

3. Pro-adipogenic Effects of all-trans Retinoic Acid in Avian Embryos. 2022. (3rd Place Poster Competition at CFAES Research Forum).

    

4. Myostatin Mutation in Japanese Quail Increasing Egg Size but Reduced Eggshell Thickness and Strength. 2022. (2nd Place Poster Competition at CFAES Research Forum).

 

국외 전문 학술지

N

Authors

Title

Journal

Volume

Page

Year

1

Kim DH*, Lee J*, Lee K.

Sexual dimorphic effect of myostatin mutation on fat accumulation in Japanese quail.

Poult. Sci.

103(8)

103951

2024

2

Kim DH, Lee J, Ko J. Lee K.

Melanophilin regulates dendritogenesis in melanocytes for feather pigmentation.

Commun Biol.

7(1)

592

2024

3

Lee J, Kim DH, Lee K.

Myostatin gene role in regulating traits of poultry species for potential industrial applications.

J Anim Sci Biotechnol.

15(1)

82

2024

4

Kim SH, Shin SH, Kim SM, Jung SE, Shin BJ, Ahn JS, Lim KT, Kim DH, Lee K, Ryu BY.

Bisphenol Analogs Downregulate the Self-Renewal Potential of Spermatogonial Stem Cells.

World J Mens Health

42

e37

2024

5

Kim DH, Lee J, Lee B, Lee K.

Muscle hypertrophy is associated with reversed sexual dimorphism in body size of quail.

Poult. Sci.

103(1)

103263

2024

6

Lee J*, Kim DH*, Lee K.

Injection of adenoviral CRISPR/Cas9 system targeting melanophilin gene into different sites of embryos induced regional feather color changes in posthatch quail.

Poult. Sci.

102(11)

103087

2023

7

Lee B*, Kim DH*, Lee J, Cressman M, Choi YM, Lee K.

Greater numbers and sizes of muscle bundles in the breast and leg muscles of broilers compared to layer chickens.

Front. Physiol.

14

1285938

2023

8

Lee J, Tompkins Y, Kim DH, Kim WK, Lee K.

The effects of myostatin mutation on the tibia bone quality in female Japanese quail before and after sexual maturation.

Poult. Sci.

102(7)

102734

2023

9

Kim DH*, Lee B*, Lee J, Bohrer BM, Choi YM, Lee K.

Effects of a myostatin mutation in Japanese quail (Coturnix japonica) on the physicochemical and histochemical characteristics of the pectoralis major muscle.

Front. Physiol.

14

1172884

2023

10

Kim DH, Lee J, Lee C, Shin BJ, Ryu BY, Lee K.

In ovo injection of all-trans retinoic acid causes adipocyte hypertrophy in embryos but lost its effect in posthatch chickens.

Animal

17(4)

100750

2023

11

Lee J, Tompkins Y, Kim DH, Kim WK, Lee K.

Increased sizes and improved qualities of tibia bones by myostatin mutation in Japanese quail.

Front. Physiol.

13

1085935

2023

12

Kim DH*, Lee J*, Choi YM, Lee K.

Growth promoting potential in Mstn mutant quail dependent and independent of increased egg size.

Poult. Sci.

102(1)

102260

2023

13

Lee J, Kim DH, Karolak MC, Shin S, Lee K.

Generation of genome-edited chicken and duck lines by adenovirus-mediated in vivo genome editing.

Proc. Natl. Acad. Sci.

119(45)

e2214344119

2022

14

Ahn J*, Kim DH*, Park MR*, Suh Y, Lee H, Hwang S, et al.

A novel testis-enriched gene, Samd4a, regulates spermatogenesis as a spermatid-specific factor.

Front. Cell Dev. Biol.

10

978343

2022

15

Jang JH, Lee JW, Cho MJ, Hwang B, Kwon MG, Kim DH, et al.

KLHL3 deficiency in mice ameliorates obesity, insulin resistance, and nonalcoholic fatty liver disease by regulating energy expenditure.

Exp. Mol. Med.

54(8)

1250?1261

2022

16

Ahn J, Lee J, Kim DH, Hwang IS, Park MR, Cho IC, et al.

Loss of Monoallelic Expression of IGF2 in the Adult Liver Via Alternative Promoter Usage and Chromatin Reorganization.

Front. Genet.

13

920641

2022

17

Kim DH, Ahn J, Suh Y, Ziouzenkova O, Lee JW, Lee K.

Retinol Binding Protein 7 Promotes Adipogenesis in vitro and Regulates Expression of Genes Involved in Retinol Metabolism.

Front. Cell Dev. Biol.

10

876031

2022

18

Kim DH, Lee J, Suh Y, Ko JK, Lee K.

Transdifferentiation of Myoblasts Into Adipocytes by All-Trans-Retinoic Acid in Avian.

Front. Cell Dev. Biol.

10

856881

2022

19

Kim DH, Choi YM, Lee J, Shin S, Kim S, Suh Y, Lee K.

Differential Expression of MSTN Isoforms in Muscle between Broiler and Layer Chickens.

Animals

12(5)

539

2022

20

Lee J, McCurdy C, Chae C, Hwang J, Karolak MC, Kim DH, et al.

Myostatin Mutation in Japanese Quail Increased Egg Size but Reduced Eggshell Thickness and Strength.

Animals

12(1)

47

2022

21

Kim JY, Lee B, Kim DH, Lee K, Kim EJ, Choi YM.

Sensory Quality and Histochemical Characteristics of Longissimus Thoracis Muscles between Hanwoo and Holstein Steers from Different Quality Grades.

Food Sci. Anim. Resour.

41(5)

779?787

2021

22

Lee J*, Kim DH*, Brower AM, Schlachter I, Lee K.

Effects of Myostatin Mutation on Onset of Laying, Egg Production, Fertility, and Hatchability.

Animals

11(7)

1935

2021

23

Kim DH, Lee J, Suh Y, Cressman M, Lee K.

Adipogenic differentiation of embryonic fibroblasts of chicken, turkey, duck, and quail in vitro by medium containing chicken serum alone.

Poult. Sci.

100(8)

101277

2021

24

Lee J*, Kim DH*, Brower AM, Schlachter I, Lee K.

Improved feed efficiency in quail with targeted genome editing in the myostatin gene.

Poult. Sci.

100(8)

101257

2021

25

Kim DH*, Lee J*, Kim S, Lillehoj HS, Lee K.

Hypertrophy of Adipose Tissues in Quail Embryos by in ovo Injection of All-Trans Retinoic Acid.

Front. Physiol.

12

681562

2021

26

Lee J*, Kim DH*, Suh Y, Lee K.

Potential usage of DF-1 cell line as a new cell model for avian adipogenesis.

Poult. Sci.

100(5)

101057

2021

27

Kim DH, Choi YM, Suh Y, Shin S, Lee J, Hwang S, et al.

Increased myostatin expression and decreased expression of myogenic regulatory factors in embryonic ages in a quail line with muscle hypoplasia.

Poult. Sci.

100(4)

100978

2021

28

Kim DH, Lee J, Suh Y, Lee K.

Necessity for Validation of Effectiveness of Selected Guide RNA In Silico for Application of CRISPR/Cas9.

Mol. Biotechnol.

63(2)

140?149

2021

29

Kim DH, Lee J, Suh Y, Cressman M, Lee K.

All-trans retinoic acids induce adipogenic differentiation of chicken embryonic fibroblasts and preadipocytes.

Poult. Sci.

99(12)

7142?7146

2020

30

Lee J, Kim DH, Lee K.

Current approaches and applications in avian genome editing.

Int. J. Mol. Sci.

21(11)

3937

2020

31

Kim DH, Choi YM, Suh Y, Shin S, Lee J, Hwang S, et al.

Association of temporal expression of myostatin with hypertrophic muscle growth in different Japanese quail lines.

Poult. Sci.

99(6)

2926?2930

2020

32

Lee J*, Kim D H*, Lee K.

Muscle hyperplasia in Japanese quail by single amino acid deletion in MSTN propeptide.

Int. J. Mol. Sci.

21(4)

1504

2020

33

Kim DH, Lee J, Suh Y, Cressman M, Lee SS, Lee K.

Adipogenic and Myogenic Potentials of Chicken Embryonic Fibroblasts in vitro: Combination of Fatty Acids and Insulin Induces Adipogenesis.

Lipids

55(2)

163?171

2020

34

Cho IC, Park HB, Ahn JS, Han SH, Lee JB, Lim HT, Yoo CK, Jung EJ, Kim DH, et al.

A functional regulatory variant of MYH3 influences muscle fiber-type composition and intramuscular fat content in pigs.

PLoS Genet.

15(10)

e1008279

2019

35

Kim DH, Lee JW, Lee K.

Supplementation of All-Trans-Retinoic Acid Below Cytotoxic Levels Promotes Adipogenesis in 3T3-L1 Cells.

Lipids

54(1)

99?107

2019

36

Ahn JS*, Kim DH*, Park HB, Han SH, Hwang S, Cho IC, et al.

Ectopic overexpression of porcine Myh1 increased in slow muscle fibers and enhanced endurance exercise in transgenic mice.

Int. J. Mol. Sci.

19(10)

2959

2018

37

Ahn J, Kim DH, Suh Y, Lee JW, Lee K.

Adipose-specific expression of mouse Rbp7 gene and its developmental and metabolic changes.

Gene

670

38?45

2018

38

Kwon DJ*, Kim DH*, Hwang IS*, Kim DE, Kim HJ, Kim JS, et al.

Generation of α-1,3-galactosyltransferase knocked-out transgenic cloned pigs with knocked-in five human genes.

Transgenic Res.

26(1)

153?163

2017

39

Sun WS, Chun JL, Kim DH, Ahn JS, Kim MK, Hwang IS, et al.

Molecular cloning and characterization of porcine ribosomal protein L21.

J. Vet. Sci.

18(4)

531?540

2017

40

Sun WS, Chun JL, Do JT, Kim DH, Ahn JS, Kim MK, et al.

Construction of a Dual-Fluorescence Reporter System to Monitor the Dynamic Progression of Pluripotent Cell Differentiation.

Stem Cells Int.

2016

1390284

2016

41

Jang H, Kim HJ, Kim DH, Park JK, Sun WS, Hwang S, et al.

Small heterodimer partner-interacting leucine zipper protein inhibits adipogenesis by regulating peroxisome proliferator-activated receptor γ activity.

Life Sci.

132

49?54

2015

42

Lim JJ, Lee JI, Kim DH, Song SH, Kim HJ, Lee WS, et al.

DNA fragmentation of human sperm can be detected by ligation-mediated real-time polymerase chain reaction.

Fertil. Steril.

100(6)

1564-71.e1?5

2013

43

Kim JS, Song BS, Lee KS, Kim DH, Kim SU, Choo YK, et al.

Tauroursodeoxycholic acid enhances the pre-implantation embryo development by reducing apoptosis in pigs.

Reprod. Domest. Anim.

47(5)

791?798

2012

44

Park YS, Park HD, Kim DH.

Effects of the In vitro Produced Hanwoo Blastocyst Stage, in vitro Culture Day and Blastocyst Grade on the Production of Calves,

Korean J Emb Trans,

21

299-306

2006

(* indicates equal contributions)

   

    

국내 전문 학술지

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Authors

Title

Journal

Volume

Page

Year

    

    

    

    

    

    

    

 

   

정부출연 개발과제 수행실적(최근 5)

번 호

프로그램명

(시행부처/기관)

과 제 명

총개발기간

(시작-종료일)