■ 학력
2010. 03 ~ 2014. 08 포항공과대학교 화학과 이학사
2014. 09 ~ 2019. 08 포항공과대학교 화학과 이학박사
■ 경력
2019. 09 ~ 2020. 10 포항공과대학교, 박사 후 연구원
2020. 12 ~ 2022. 07 The Scripps Research Institute, 박사 후 연구원
■ 전공분야
Ribonuclease를 이용한 질병 관련 RNA 분해
질병 관련 비코딩 RNA 기능 저해
단백질 단백질 간 상호작용
■ 연구 논문
1. Lee, Y. †; Liu X. †; Tong, Y. †; Child-Disney, J. †; Suresh, B.M.; Benhanou, R. I.; Sievers, S.; Grefe, M.; Crynen, G.; Meter, M. V.; Costales, M. G.; Abegg, D.; Haniff, H. S.; Wegner, T.; Paulisch, T. O.; Adibekian, A.; Lekah, E.; Glorius, F.; Waldmann, H.; Disney, M. D; “Biologically inactive RNA binding small molecules are rendered bioactive when converted into degraders” Nature, under revision †Contributed equally
2. Lee, Y.; Heo, J.; Jeong, H.; Hong, K. T.; Kwon, D. H.; Shin, M. H.; Oh, M.; Sable, G. A.; Ahn, G.; Lee, J. S.; Lim, H. S. “Targeted Degradation of Transcription Co-activator SRC-1 through the N-Degron Pathway.” Angew. Chem. Int. Ed. 2020,59, 17548-17555.
3.
Lee, Y.; Im, H.; Oh, M.; Lee, J. H.;
Das, S.; Ham, S.; Lim, H. S. “Bridged α-helix mimetic small
molecules.” Chem. Commun.
4.
Lee, Y.; Chung, B.; Ko, D. S.; Lim, H.
S.“A solid-phase
method for synthesis of dimeric and trimeric ligands: Identification of potent
bivalent ligands of 14-3-3σ." Bioorg.
Chem.
5. Lee, Y.; Yoon, H.; Hwang, S. M.; Shin, M. K.; Lee, J. H.; Oh, M.; Im, S. H.; Song, J.; Lim, H. S. “Targeted Inhibition of the NCOA1/STAT6 Protein-Protein Interaction.” J. Am. Chem. Soc. 2017, 139, 16056-16059.
6.
Lee,
Y.; Lim, H. S. “Skp2
inhibitors: Novel anticancer strategies.” Curr.
Med. Chem.
7.
Kim,
H.-S.; Lee, Y.; Shin, M. H.; Lim, H.
S. "Cell-Penetrating, Amphipathic Cyclic Peptoids as Molecular
Transporters for Cargo Delivery" Chem.
Commun.
8. Castaneda, M.; Chen, L.; Pradhan, L.; Li, S.; Zein, R.; Lee, Y.; Lim, H. S.; Nam, H.J.; Lee, J. "A Forkhead Box Protein?C2 Inhibitor: Targeting Epithelial-Mesenchymal Transition and Cancer Metastasis. Chembiochem, 2018, 19, 1359-1364.
■ 특허
1. H. S. Lim, Y. Lee, “Novel staple peptides for inhibiting NCOA1/STAT6 protein-protein interaction and uses thereof”, Korea Patent 10-2017-0139637 (2017) / 10-2043992 (2019)
2. H. S. Lim, Y. Lee, “Novel PROTAC chimeric compound, and pharmaceutical composition for preventing, improving or treating diseases through target protein degradation”, Korea Patent, 10-2020-0081373 (2020)